Synthesis and antibacterial activities of less chlorinated analogs of neopyrrolomycin.

structurally unique phenylpyrrole antibiotic. 1} Very recently, ( +)and (~)-neopyrrolomycins (1)2) and their analogs3) were synthesized from 3,5-dichloroanisole in our laboratories.4) Herein we report the synthesis of a variety of less chlorinated analogs (2 14) and their structure-activity relationship. All analogs (2~14) were synthesized from 2aminoanisoles 15a~15d by our procedures as reported previously.2~4) The compound 15a (oil)